MovDisordV3, Main, Exploration, bibRecord, 002786

Levodopa therapy in a Lesch‐Nyhan disease patient: Pathological, biochemical, neuroimaging, and therapeutic remarks

Identifieur interne : 002786 ( Main/Exploration ); précédent : 002785; suivant : 002787

Levodopa therapy in a Lesch‐Nyhan disease patient: Pathological, biochemical, neuroimaging, and therapeutic remarks

Auteurs : Mercedes Serrano [Espagne] ; Belen Pérez-Due As [Espagne] ; Aida Ormazábal [Espagne] ; Rafael Artuch [Espagne] ; Jaume Campistol [Espagne] ; Rosa J. Torres [Espagne] ; Angels García-Cazorla [Espagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2008-07-15.

RBID : ISTEX:8F906D401E9E5ECA8BAAD488E8786A4F7E27FA2F

Descripteurs français

Pascal (Inist)
- Dopamine, Homme, Liquide céphalorachidien, Lévodopa, Neuromédiateur, Neurotransmetteur, Pathologie du système nerveux, Ponction lombaire, Traitement.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Cerebrospinal fluid, Child, Preschool, Dopamine, Dopamine Agents (therapeutic use), Human, Humans, Lesch-Nyhan Syndrome (drug therapy), Lesch-Nyhan Syndrome (metabolism), Lesch-Nyhan Syndrome (pathology), Lesch‐Nyhan disease, Levodopa, Levodopa (therapeutic use), Lumbar puncture, Male, Nervous system diseases, Neuromediator, Neurotransmitter, Treatment, Treatment Outcome, cerebrospinal fluid, dopamine, lumbar puncture, monoamines, neurotransmitter.
MESH :
- chemical , therapeutic use : Dopamine Agents, Levodopa.
- drug therapy : Lesch-Nyhan Syndrome.
- metabolism : Lesch-Nyhan Syndrome.
- pathology : Lesch-Nyhan Syndrome.
- Child, Preschool, Humans, Male, Treatment Outcome.

Abstract

Lesch‐Nyhan disease (LND) is a hereditary disorder of purine metabolism causing severe neurobehavioral disturbances in which an abnormal central nervous system dopaminergic function has been implied. However, levodopa treatment has rarely been used, and reports describe heterogeneous responses. We report an LND patient with low dopamine metabolite values in cerebrospinal fluid for whom early levodopa/carbidopa therapy was begun with a notable clinical improvement. We propose that very early treatment of LND patients with levodopa may improve their neurological symptoms and may contribute to a better outcome. © 2008 Movement Disorder Society

Url:

https://api.istex.fr/document/8F906D401E9E5ECA8BAAD488E8786A4F7E27FA2F/fulltext/pdf

DOI: 10.1002/mds.21786

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Levodopa therapy in a Lesch‐Nyhan disease patient: Pathological, biochemical, neuroimaging, and therapeutic remarks</title>
<author><name sortKey="Serrano, Mercedes" sort="Serrano, Mercedes" uniqKey="Serrano M" first="Mercedes" last="Serrano">Mercedes Serrano</name>
</author>
<author><name sortKey="Perez Ue As, Belen" sort="Perez Ue As, Belen" uniqKey="Perez Ue As B" first="Belen" last="Pérez-Due As">Belen Pérez-Due As</name>
</author>
<author><name sortKey="Ormazabal, Aida" sort="Ormazabal, Aida" uniqKey="Ormazabal A" first="Aida" last="Ormazábal">Aida Ormazábal</name>
</author>
<author><name sortKey="Artuch, Rafael" sort="Artuch, Rafael" uniqKey="Artuch R" first="Rafael" last="Artuch">Rafael Artuch</name>
</author>
<author><name sortKey="Campistol, Jaume" sort="Campistol, Jaume" uniqKey="Campistol J" first="Jaume" last="Campistol">Jaume Campistol</name>
</author>
<author><name sortKey="Torres, Rosa J" sort="Torres, Rosa J" uniqKey="Torres R" first="Rosa J." last="Torres">Rosa J. Torres</name>
</author>
<author><name sortKey="Garcia Azorla, Angels" sort="Garcia Azorla, Angels" uniqKey="Garcia Azorla A" first="Angels" last="García-Cazorla">Angels García-Cazorla</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:8F906D401E9E5ECA8BAAD488E8786A4F7E27FA2F</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.21786</idno>
<idno type="url">https://api.istex.fr/document/8F906D401E9E5ECA8BAAD488E8786A4F7E27FA2F/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001688</idno>
<idno type="wicri:Area/Istex/Curation">001688</idno>
<idno type="wicri:Area/Istex/Checkpoint">001342</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Serrano M:levodopa:therapy:in</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:18528895</idno>
<idno type="wicri:Area/PubMed/Corpus">002205</idno>
<idno type="wicri:Area/PubMed/Curation">002205</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002237</idno>
<idno type="wicri:Area/Ncbi/Merge">002158</idno>
<idno type="wicri:Area/Ncbi/Curation">002158</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002158</idno>
<idno type="wicri:Area/Main/Merge">003364</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:08-0396192</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001193</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001B26</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001210</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Serrano M:levodopa:therapy:in</idno>
<idno type="wicri:Area/Main/Merge">003818</idno>
<idno type="wicri:Area/Main/Curation">002786</idno>
<idno type="wicri:Area/Main/Exploration">002786</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Levodopa therapy in a Lesch‐Nyhan disease patient: Pathological, biochemical, neuroimaging, and therapeutic remarks</title>
<author><name sortKey="Serrano, Mercedes" sort="Serrano, Mercedes" uniqKey="Serrano M" first="Mercedes" last="Serrano">Mercedes Serrano</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurology Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centre for Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perez Ue As, Belen" sort="Perez Ue As, Belen" uniqKey="Perez Ue As B" first="Belen" last="Pérez-Due As">Belen Pérez-Due As</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurology Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centre for Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ormazabal, Aida" sort="Ormazabal, Aida" uniqKey="Ormazabal A" first="Aida" last="Ormazábal">Aida Ormazábal</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centre for Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Clinical Biochemistry Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Artuch, Rafael" sort="Artuch, Rafael" uniqKey="Artuch R" first="Rafael" last="Artuch">Rafael Artuch</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centre for Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Clinical Biochemistry Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Campistol, Jaume" sort="Campistol, Jaume" uniqKey="Campistol J" first="Jaume" last="Campistol">Jaume Campistol</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurology Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centre for Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Torres, Rosa J" sort="Torres, Rosa J" uniqKey="Torres R" first="Rosa J." last="Torres">Rosa J. Torres</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Division of Clinical Biochemistry, La Paz University Hospital, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Garcia Azorla, Angels" sort="Garcia Azorla, Angels" uniqKey="Garcia Azorla A" first="Angels" last="García-Cazorla">Angels García-Cazorla</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurology Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centre for Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-07-15">2008-07-15</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">9</biblScope>
<biblScope unit="page" from="1297">1297</biblScope>
<biblScope unit="page" to="1300">1300</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">8F906D401E9E5ECA8BAAD488E8786A4F7E27FA2F</idno>
<idno type="DOI">10.1002/mds.21786</idno>
<idno type="ArticleID">MDS21786</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebrospinal fluid</term>
<term>Child, Preschool</term>
<term>Dopamine</term>
<term>Dopamine Agents (therapeutic use)</term>
<term>Human</term>
<term>Humans</term>
<term>Lesch-Nyhan Syndrome (drug therapy)</term>
<term>Lesch-Nyhan Syndrome (metabolism)</term>
<term>Lesch-Nyhan Syndrome (pathology)</term>
<term>Lesch‐Nyhan disease</term>
<term>Levodopa</term>
<term>Levodopa (therapeutic use)</term>
<term>Lumbar puncture</term>
<term>Male</term>
<term>Nervous system diseases</term>
<term>Neuromediator</term>
<term>Neurotransmitter</term>
<term>Treatment</term>
<term>Treatment Outcome</term>
<term>cerebrospinal fluid</term>
<term>dopamine</term>
<term>lumbar puncture</term>
<term>monoamines</term>
<term>neurotransmitter</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lesch-Nyhan Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lesch-Nyhan Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lesch-Nyhan Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Child, Preschool</term>
<term>Humans</term>
<term>Male</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Dopamine</term>
<term>Homme</term>
<term>Liquide céphalorachidien</term>
<term>Lévodopa</term>
<term>Neuromédiateur</term>
<term>Neurotransmetteur</term>
<term>Pathologie du   système nerveux</term>
<term>Ponction lombaire</term>
<term>Traitement</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Lesch‐Nyhan disease (LND) is a hereditary disorder of purine metabolism causing severe neurobehavioral disturbances in which an abnormal central nervous system dopaminergic function has been implied. However, levodopa treatment has rarely been used, and reports describe heterogeneous responses. We report an LND patient with low dopamine metabolite values in cerebrospinal fluid for whom early levodopa/carbidopa therapy was begun with a notable clinical improvement. We propose that very early treatment of LND patients with levodopa may improve their neurological symptoms and may contribute to a better outcome. © 2008 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Catalogne</li>
<li>Communauté de Madrid</li>
</region>
<settlement><li>Barcelone</li>
<li>Madrid</li>
</settlement>
</list>
<tree><country name="Espagne"><region name="Catalogne"><name sortKey="Serrano, Mercedes" sort="Serrano, Mercedes" uniqKey="Serrano M" first="Mercedes" last="Serrano">Mercedes Serrano</name>
</region>
<name sortKey="Artuch, Rafael" sort="Artuch, Rafael" uniqKey="Artuch R" first="Rafael" last="Artuch">Rafael Artuch</name>
<name sortKey="Artuch, Rafael" sort="Artuch, Rafael" uniqKey="Artuch R" first="Rafael" last="Artuch">Rafael Artuch</name>
<name sortKey="Campistol, Jaume" sort="Campistol, Jaume" uniqKey="Campistol J" first="Jaume" last="Campistol">Jaume Campistol</name>
<name sortKey="Campistol, Jaume" sort="Campistol, Jaume" uniqKey="Campistol J" first="Jaume" last="Campistol">Jaume Campistol</name>
<name sortKey="Garcia Azorla, Angels" sort="Garcia Azorla, Angels" uniqKey="Garcia Azorla A" first="Angels" last="García-Cazorla">Angels García-Cazorla</name>
<name sortKey="Garcia Azorla, Angels" sort="Garcia Azorla, Angels" uniqKey="Garcia Azorla A" first="Angels" last="García-Cazorla">Angels García-Cazorla</name>
<name sortKey="Ormazabal, Aida" sort="Ormazabal, Aida" uniqKey="Ormazabal A" first="Aida" last="Ormazábal">Aida Ormazábal</name>
<name sortKey="Ormazabal, Aida" sort="Ormazabal, Aida" uniqKey="Ormazabal A" first="Aida" last="Ormazábal">Aida Ormazábal</name>
<name sortKey="Perez Ue As, Belen" sort="Perez Ue As, Belen" uniqKey="Perez Ue As B" first="Belen" last="Pérez-Due As">Belen Pérez-Due As</name>
<name sortKey="Perez Ue As, Belen" sort="Perez Ue As, Belen" uniqKey="Perez Ue As B" first="Belen" last="Pérez-Due As">Belen Pérez-Due As</name>
<name sortKey="Serrano, Mercedes" sort="Serrano, Mercedes" uniqKey="Serrano M" first="Mercedes" last="Serrano">Mercedes Serrano</name>
<name sortKey="Torres, Rosa J" sort="Torres, Rosa J" uniqKey="Torres R" first="Rosa J." last="Torres">Rosa J. Torres</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002786 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002786 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:8F906D401E9E5ECA8BAAD488E8786A4F7E27FA2F
   |texte=   Levodopa therapy in a Lesch‐Nyhan disease patient: Pathological, biochemical, neuroimaging, and therapeutic remarks
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Levodopa therapy in a Lesch‐Nyhan disease patient: Pathological, biochemical, neuroimaging, and therapeutic remarks

Levodopa therapy in a Lesch‐Nyhan disease patient: Pathological, biochemical, neuroimaging, and therapeutic remarks

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.